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Histamine is a bioactive or “vasoactive” amine produced in the body in response to an injury or foreign substance. It has an array of physiological effects, including increasing blood supply to specific sites in the body. In addition, histamine is involved in the immune response, regulation of gastric acid, the permeability of blood vessels, contraction of muscles, and the normal response to inflammation. The highest concentrations of histamine in the body are found in the gastrointestinal tract, lungs, and skin, with lesser amounts in the brain and heart.
The imbalance between the endogenous and exogenous histamine must be broken down in order to maintain homeostasis and histamine balance. DAO, which is the enzyme diamine oxidase (DAO), degrades histamine
by converting it from 2-(4-imidazolyl)-ethylamine to the inactive metabolite imidazole acetaldehyde. The active ingredient in DAO is porcine-derived diamine oxidase, and research suggests that DAO derived from porcine kidney appears to have identical action to DAO derived from porcine intestine. In humans and other mammals, DAO is found in high concentrations in the gastrointestinal mucosa. Animal studies suggest that circulating DAO may be a marker for mucosal integrity and maturity. Certain drugs may affect histamine balance in the body by promoting histamine release or inhibiting DAO. Histamine tolerance may not be the same for everyone.
Results of a double-blind, placebo-controlled crossover study suggest that tolerance to histamine can vary from individual to individual. Total body histamine load must be considered when evaluating histamine tolerance, and a balance between histamine and DAO appears to be crucial to maintaining skin, rhino-conjunctival, and gastrointestinal health. Genetic and environmental factors may interact to influence DAO expression. Ongoing research addresses the role that genetic variation may play in individual differences in DAO metabolism, and serum activity was significantly associated with seven single nucleotide variations within the DAO gene. Histamine tolerance may be reflected in detailed questionnaires, food intake logs, trials with a low-histamine diet, and measurement of DAO and histamine.
DAO is a patented enzyme formula containing diamine oxidase (DAO)—the main enzyme responsible for the degradation of ingested histamine. This enzyme has been clinically tested and found to break down food-derived histamine in the digestive tract. DAO is not absorbed and does not have systemic activity. DAO does support IgG and IgA antibody reactions. DAO does not manage or address antibody-related or IgE-related allergies.
Supports healthy degradation of food-derived histamine; enhances the presence of diamine oxidase in the digestive tract.
Wheat, gluten, yeast, soy, dairy products, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or artificial preservatives.
Take two capsules before bed or take as directed by your healthcare practitioner.