Nitric Oxide and Female Infertility

Commonly used by athletes for enhanced muscular performance and men to treat erectile dysfunction, nitric oxide is now being leveraged as a tool to help women achieve conception. Our body naturally produces Nitric oxide through the oxidation of the amino acid L-Arginine.

Nitric oxide could be beneficial especially for older women trying to conceive. In a study, published in the journal Biochemistry, researchers studied its impact in mice. They took a sample of 1,500 eggs immediately after ovulation and exposed them to nitric oxide.

They believe that the outer shells of the eggs took longer to harden after the exposure and that nitric oxide blunts the effects of aging of ageing on their ovaries, which could negatively impact fertilization. Researchers also believe that that nitric oxide may protect against spontaneous miscarriages and genetic abnormalities during early embryo development in older women.

Here’s a closer look at other Nitric Oxide benefits:

  • Nitric oxide facilitates vasodilation i.e. better circulation to organs including the reproductive system.


  • The increased increase blood flow can improve ovarian response and stimulation in cases of poor ovarian reserve or in poor ovarian responders.


  • Helps the body produce cervical fluids needed to conceive e.g. cervical mucus, which is essential to carry the sperm to the egg.


  • Nitric oxide may boost the chances of a successful IVF cycle because it enhances fertility of harvested eggs.


  • It can boost yours and your partner’s sexual drive.


  • It improves blood flow to the uterine cavity, which can help in implantation after embryo transfer.